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研究紹介

2022年 研究業績

英文業績

Pub-Med

  1. Tsujiura M, Yamamoto A, Imaoka H, Shimura T, Kitajima T, Morimoto Y, Kawamura M, Yasuda H, Okita Y, Yokoe T, Okugawa Y, Ohi M, Toiyama Y. Clinical utility of lymphocyte to C-reactive protein ratio in predicting survival and postoperative complication for esophago-gastric junction cancer. Surg Oncol. 2022 Sep; 44:101842. doi: 10.1016/j.suronc.2022.101842. Epub 2022 Aug 30.
  2. Yin C, Okugawa Y, Yamamoto A, Kitajima T, Shimura T, Kawamura M, Tsujiura M, Okita Y, Ohi M, Toiyama Y. Prognostic significance of CD8+ tumor-infiltrating lymphocytes and CD66b+ tumor-associated neutrophils in the invasive margins of stages I-III colorectal cancer. Oncol Lett. 2022 May 17;24(1):212. doi: 10.3892/ol.2022.13333. eCollection 2022 Jul.
  3. Okugawa Y, Kitajima T, Yamamoto A, Shimura T, Kawamura M, Fujiwara T, Mochiki I, Okita Y, Tsujiura M, Yokoe T, Ohi M, Toiyama Y. Clinical Relevance of Myopenia and Myosteatosis in Colorectal Cancer. J Clin Med. 2022 May 6;11(9):2617. doi: 10.3390/jcm11092617.
  4. Koike Y, Yin C, Sato Y, Nagano Y, Yamamoto A, Kitajima T, Shimura T, Kawamura M, Matsushita K, Okugawa Y, Amano K, Otake K, Okita Y, Ohi M, Inoue M, Uchida K, Hirayama M, Toiyama Y. TPX2 is a prognostic marker and promotes cell proliferation in neuroblastoma. Oncol Lett. 2022 Apr;23(4):136.
  5. Shimura T, Kandimalla R, Okugawa Y, Ohi M, Toiyama Y, He C, Goel A.
    Novel evidence for m6A methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer. Br J Cancer. 2022 Feb;126(2):228-237. doi: 10.1038/s41416-021-01581-w. Epub 2021 Oct 21.
  6. Matsuyama T, Toiyama Y, Ishikawa T, Okugawa Y, Yasuno M, Maurel J, Kinugasa Y, Uetake H, Goel A.A metastasis-associated microRNA-based liquid biopsy signature for risk-stratification in colorectal cancer: a multicenter cohort study. Clin Transl Med. 2022 Dec;12(12): e998. doi: 10.1002/ctm2.998.
  7. Matsushima Y, Kitano M, Hayashi D, Goto H, Mine M, Yokoe T, Kondo M, Habe K, Toiyama Y, Hashimoto T, Tsuruta D, Takeuchi K, Yamanaka K. A Case of IgG and IgA Anti-Laminin-332 Antibody-Positive Mucous Membrane Pemphigoid with IgG and IgA Anti-Envoplakin and Anti-Periplakin Antibodies. Dermatopathology (Basel). 2022 Aug 8;9(3):287-291.  doi: 10.3390/dermatopathology9030034.
  8. Nakamura K, Hernández G, Sharma GG, Wada Y, Banwait JK, González N, Perea J, Balaguer F, Takamaru H, Saito Y, Toiyama Y, Kodera Y, Boland CR, Bujanda L, Quintero E, Goel A.A Liquid Biopsy Signature for the Detection of Patients With Early-Onset Colorectal Cancer.Gastroenterology. 2022 Nov;163(5):1242-1251.e2. doi: 10.1053/j.gastro.2022.06.089.
  9. Roy S, Kanda M, Nomura S, Zhu Z, Toiyama Y, Taketomi A, Goldenring J, Baba H, Kodera Y, Goel A. Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer. Mol Cancer. 2022 Feb 9;21(1):42. doi: 10.1186/s12943-022-01527-7.
  10. Hishida A, Yamada H, Ando Y, Okugawa Y, Shiozawa M, Miyagi Y, Daigo Y, Toiyama Y, Shirai Y, Tanaka K, Kubo Y, Okada R, Nagayoshi M, Tamura T, Mori A, Kondo T, Hamajima N, Takeuchi K, Wakai K. Investigation of miRNA expression profiles using cohort samples reveals potential early detectability of colorectal cancers by serum miR-26a-5p before clinical diagnosis. Oncol Lett. 2022 Mar;23(3):87. doi: 10.3892/ol.2022.13207. Epub 2022 Jan 21.
  11. Kudo T, Jimbo K, Shimizu H, Iwama I, Ishige T, Mizuochi T, Arai K, Kumagai H, Uchida K, Abukawa D, Shimizu T. Qing-Dai for pediatric ulcerative colitis multicenter survey and systematic review. Pediatr Int. 2022 Jan;64(1): e15113. doi: 10.1111/ped.15113.
  12. Nagata Y, Kageyama S, Ishikawa T, Kokura S, Okayama T, Abe T, Murakami M, Otsuka K, Ariyoshi T, Kojima T, Taniguchi K, Kobayashi S, Shimada H, Yajima S, Suzuki T, Hirano S, Tsuchikawa T, Shichinohe T, Ueda S, Kanetaka K, Yoneda A, Wada H, Doki Y, Yamaue H, Katsuda M, Ohi M, Yasuda H, Kondo K, Kataoka M, Kodera Y, Koike M, Shiraishi T, Miyahara Y, Goshima N, Fukuda E, Yamaguchi K, Sato E, Ikeda H, Yamada T, Osako M, Hirai K, Miyamoto H, Watanabe T, Shiku H. Prognostic significance of NY-ESO-1 antigen and PIGR expression in esophageal tumors of CHP-NY-ESO-1-vaccinated patients as adjuvant therapy. Cancer Immunol Immunother. 2022 Nov;71(11):2743-2755. doi: 10.1007/s00262-022-03194-5. Epub 2022 Apr 16.
  13. Suzuki K, Yoshida H, Esumi R, Ieki Y, Yamamoto A, Ohi M, Kaneko T, Imai H. Esophageal Perforation Accompanying Mediastinitis in Blunt Trauma in a Patient with Thoracic Osteophytes. Intern Med. 2022 Sep 1;61(17):2601-2605. doi: 10.2169/internalmedicine.8930-21. Epub 2022 Feb 8.
  14. Takahashi K, Shigeyasu K, Kondo Y, Gotoh K, Yano S, Umeda Y, Inokuchi T, Xu C, Yoshida K, Umeda H, Takahashi T, Takeda S, Yoshida R, Teraishi F, Kishimoto H, Mori Y, Noma K, Okugawa Y, Hiraoka S, Michiue H, Tazawa H, Matsushita O, Goel A, Fujiwara T. RNA editing is a valuable biomarker for predicting carcinogenesis in ulcerative colitis. J Crohns Colitis. 2022 Dec 18: jjac186. doi: 10.1093/ecco-jcc/jjac186.Epub 
  15. Shirai Y, Momosaki R, Kokura Y, Kato Y, Okugawa Y, Shimizu A. Validation of Asian Body Mass Index Cutoff Values for the Classification of Malnutrition Severity According to the Global Leadership Initiative on Malnutrition Criteria in Patients with Chronic Obstructive Pulmonary Disease Exacerbations. Nutrients. 2022 Nov 10;14(22):4746. doi: 10.3390/nu14224746.
  16. Nimura R, Kondo E, Yoshida K, Kubo-Kaneda M, Nii M, Ikeijiri M, Nakamura M, Imai H, Okugawa Y, Nakatani K, Ikeda T. Cancer-associated gene analysis of cervical cytology samples and liquid-based cytology significantly improve endometrial cancer diagnosis sensitivity. Oncol Lett. 2022 Sep 8;24(4):376. doi: 10.3892/ol.2022.13496. eCollection 2022 Oct. Mol Genet Metab Rep. 2022 Sep 26; 33:100919. doi: 10.1016/j.ymgmr.2022.100919. eCollection 2022 Dec.
  17. Shen JS, Balaji U, Shigeyasu K, Okugawa Y, Jabbarzadeh-Tabrizi S, Day TS, Arning E, Marshall J, Cheng SH, Gu J, Schiffmann R, Bottiglieri T, Goel A.Dysregulated DNA methylation in the pathogenesis of Fabry disease.Mol Genet Metab Rep. 2022 Sep 26; 33:100919. doi: 10.1016/j.ymgmr.2022.100919. eCollection 2022 Dec.
  18. Mochiki I, Okugawa Y, Hashizume R, Imai H, Ikejiri M, Ogura T, Nakatani K, Hori H. Psychological characteristics of Japanese patients and their family members receiving genetic counseling: A single-institute exploratory study. J Genet Couns. 2022 Aug 25. doi: 10.1002/jgc4.1629.Epub 
  19. Shirai Y, Morita S, Iwata T, Nakai H, Yoshikawa M, Yoshida K, Iwamoto H, Miyaji K, Okugawa Y, Miki C, Tanaka K. Anti-inflammatory and nutritional improvement effects of dietary supplementation combined with fish oil in patients with epithelial cancer. Oncol Lett. 2022 Jul 12;24(3):306. doi: 10.3892/ol.2022.13426. eCollection 2022 Sep.
  20. Hane A, Ito A, Ishikura K, Imai H, Okugawa Y. Cardiac Arrest Induced by an Anaphylactic Reaction Associated With the First Dose of Cetuximab. Cureus. 2022 Jun 26;14(6): e26351. doi: 10.7759/cureus.26351. eCollection 2022 Jun.
  21. Higashi S, Sasaki T, Uchida K, Kageyama T, Ikejiri M, Matsumoto R, Kato M, Masui S, Yoshio Y, Nishikawa K, Okugawa Y, Watanabe M, Inoue T. Succinate dehydrogenase B-deficient renal cell carcinoma with a germline variant in a Japanese patient: a case report. Hum Genome Var. 2022 Jul 22;9(1):25. doi: 10.1038/s41439-022-00202-z.
  22. Terui K, Nagata K, Yamoto M, Hayakawa M, Okuyama H, Amari S, Yokoi A, Furukawa T, Masumoto K, Okazaki T, Inamura N, Toyoshima K, Koike Y, Okawada M, Sato Y, Usui N. A predictive scoring system for small diaphragmatic defects in infants with congenital diaphragmatic hernia. Pediatr Surg Int. 2022 Nov 28;39(1):4. doi: 10.1007/s00383-022-05287-9.
  23. Kono J, Nagata K, Terui K, Amari S, Toyoshima K, Inamura N, Koike Y, Yamoto M, Okazaki T, Yazaki Y, Okuyama H, Hayakawa M, Furukawa T, Masumoto K, Yokoi A, Usui N, Tajiri T. The efficacy of the postnatal nasogastric tube position as a prognostic marker of left-sided isolated congenital diaphragmatic hernia. Pediatr Surg Int. 2022 Dec;38(12):1873-1880. doi: 10.1007/s00383-022-05226-8. Epub 2022 Sep 23.
  24. Zozaya C, Ganji N, Li B, Janssen Lok M, Lee C, Koike Y, Gauda E, Offringa M, Eaton S, Shah PS, Pierro A. Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study. Arch Dis Child Fetal Neonatal Ed. 2023 Jan;108(1):69-76. doi: 10.1136/archdischild-2022-324174. Epub 2022 Aug 8.
  25. Yamoto M, Nagata K, Terui K, Hayakawa M, Okuyama H, Amari S, Yokoi A, Masumoto K, Okazaki T, Inamura N, Toyoshima K, Koike Y, Yazaki Y, Furukawa T, Usui N. Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan.Children (Basel). 2022 Jun 8;9(6):856. doi: 10.3390/children9060856.
  26. Nishiwada S, Shimura T, Yamamura K, Nakagawa K, Nagai M, Nakamura K, Terai T, Yamada S, Fujii T, Kodera Y, Sho M, Goel A. Clinical significance and functional role of adhesion G-protein-coupled receptors in human pancreatic ductal adenocarcinoma. Br J Cancer. 2022 Nov 17. Epub
  27. Okugawa Y, Toiyama Y, Yin C, Ruiya M, Goel A, Ichikawa T, Imaoka H, Kitajima T, Shimura T, Kawamura M, Yasuda H, Fujikawa H, Yokoe T, Mochiki I, Ohi M, Nakatani K.Prognostic potential of METTL3 expression in patients with gastric cancer.Oncol Lett. 2022 Dec 23;25(2):64. doi: 10.3892/ol.2022.13651.

和文業績

総説

  1. 奥川喜永, 大井正貴, 北嶋貴仁, 志村匡信,大北喜基,望木郁代,横江毅,問山裕二:特集「外科代謝栄養と東洋医学:漢方による周術期管理へのサポート」.六君子湯による周術期管理へのサポート.外科と代謝・栄養.56(2):55-58, 2022
  2. 奥川喜永, 北嶋貴仁, 藤原拓海, 志村匡信,今岡裕基,川村幹雄,望木郁代,大北喜基,吉山繁幸,大井正貴,問山裕二:【特集】悪液質(炎症をともなう慢性疾患関連性低栄養)に対する最新アプローチがん薬物療法治療中における悪液質対策.臨床栄養.141(5):680-684, 2022
  3. 奥川喜永,大井正貴,藤原拓海,橋詰令太郎,今井 裕,望木郁代,中谷 中:【がんゲノム医 療-扉の向こうへ進むための基礎知識-】2次的所見の対応.癌の臨床.66(5): 331-337, 2022
  4. 大北喜基, 問山裕二:【特集】IBD術後の諸問題に対する!潰瘍性大腸炎術後回腸嚢炎の診断と治療.IBD Research.16(3):136-142
  5. 小池勇樹, 内田恵一, 井上幹大, 佐藤友紀, 長野由佳, 松下航平, 溝口明, 問山裕二: 【特集小児外科を取り巻く最新テクノロジー】消化管神経叢の生体蛍光観察. 小児外科. 54(10): 989-993, 2022
  6. 川村幹雄, 大北喜基, 問山裕二:消化器外科手術アトラス腹腔鏡下大腸全摘、J型回腸嚢肛門吻合術.消化器外科.45(4):361-372, 2022
  7. 志村匡信, 大北喜基,今岡裕基,川村幹雄,問山裕二:【病態に応じた栄養療法の重要性】炎症性腸疾患における周術期栄養管理の意義と実際.外科.84(13):1351-1355, 2022
  8. 山本晃, 大北喜基, 今岡裕基, 志村匡信, 川村幹雄, 問山裕二:【特集主題Ⅱ】ゲノム医療時代の大腸癌診療.Ⅵ.潰瘍性大腸炎関連癌の分子生物学的アプローチを用いた診断法.日本大腸肛門病学会雑誌.75(10):478-486, 2022
  9. 井上幹大, 小池勇樹,内田恵一:【特集小児外科を取り巻く最新テクノロジー】胆道閉鎖症肝門部の二光子レーザー顕微鏡による観察.小児外科.54(10):994-998, 2022

原著

  1. 問山裕二, 藤川裕之, 今岡裕基, 志村匡信, 川村幹雄, 大北喜基:本邦の大腸がん治療の現状と展望-海外における標準治療と比較して.2.大腸がんの周術期管理‐エビデンスはどこまで構築されたか―.日本外科学会雑誌.123(3): 221-227, 2022
  2. 川村幹雄, 山本 晃, 今岡裕基, 北嶋貴仁, 志村匡信, 奥川喜永, 大北喜基, 大井正貴, 問山裕二: 【大腸憩室症の診断と治療】大腸憩室症がある場合の吻合における注意点. 外科. 84(3): 247-252, 2022

症例報告

  1. 森本雄貴, 藤川裕之, 大村悠介, 山本 晃, 今岡裕基, 北嶋貴仁, 志村匡信, 川村幹雄, 安田裕美, 大北喜基, 横江 毅, 大井正貴, 問山裕二:Total Neoadjuvant Therapy後に薬物療法を追加しWatch and Waitを行った下部進行直腸癌の1例. 癌と化学療法. 49(3): 297-299, 2022
  2. 大竹耕平, 東 浩輝, 橋本 清, 家城 英治, 嶌村 麻生, 諸戸 紗依, 水越 幸輔, 尾嶋 英紀, 毛利 靖彦: 内ヘルニアが原因と考えられたメッケル憩室茎捻転の1小児例. 日本小児救急医学会雑誌. 21(1): 65-68, 2022
  3. 山下 真司, 三枝 晋, 浦谷 亮, 藤川 裕之, 毛利 智美, 田中 光司.腹腔内出血をきたした魚骨による小腸穿孔の1例. 日本臨床外科学会雑誌. 83(8):1464-1469, 2022
  4. 東 浩輝, 内田 恵一, 鈴木 仁之, 家城 英治, 嶌村 麻生, 水越 幸輔, 辻浦 誠浩, 尾嶋 英紀, 伊藤 秀樹, 毛利 靖彦:小児穿通性胸部外傷に対して胸腔鏡補助下手術が有効であった1例. 日本小児外科学会雑誌.58(6):942-945, 2022