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研究紹介

2016年 研究業績

英文業績

Pub-Med

  1. Yoshikawa T, Takeuchi H, Hasegawa S, Nozaki I, Kishi K, Ito S, Ohi M, Mine S, Hara J, Matsuda T, Hiki N, Kurokawa Y. Theoretical therapeutic impact of lymph node dissection on adenocarcinoma and squamous cell carcinoma of the esophagogastric junction. Gastric Cancer. Gastric Cancer. 2016 Jan;19(1):143-9.
  2. Toiyama Y, Tanaka K, Inoue Y, Mohri Y, Kusunoki M. Circulating cell-free microRNAs as biomarkers for colorectal cancer. Surg Today. 2016 Jan;46(1):13-24.
  3. Otake K, Uchida K, Ide S, Kobayashi Y, Kobayashi I, Kusunoki M. Identification of DDX39A as a Potential Biomarker for Unfavorable Neuroblastoma Using a Proteomic Approach. Pediatr Blood Cancer. 2016 Feb;63(2):221-7.
  4. Mohri Y, Tanaka K, Toiyama Y, Ohi M, Yasuda H, Inoue Y, Kusunoki M. Impact of Preoperative Neutrophil to Lymphocyte Ratio and Postoperative Infectious Complications on Survival After Curative Gastrectomy for Gastric Cancer: A Single Institutional Cohort Study. Medicine (Baltimore). 2016 Mar;95(11):e3125.
  5. Inoue M, Uchida K, Otake K, Nagano Y, Mori K, Hashimoto K, Matsushita K, Koike Y, Uemura A, Kusunoki M. Thoracoscopic repair of congenital diaphragmatic hernia with countermeasures against reported complications for safe outcomes comparable to laparotomy. Surg Endosc. 2016 Mar;30(3):1014-9.
  6. Toden S, Tran HM, Tovar-Camargo OA, Okugawa Y, Goel A. Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer. Oncotarget. 2016 Mar 29;7(13):16158-71.
  7. Koike Y, Uchida K, Nagano Y, Matsushita K, Otake K, Inoue M, Kusunoki M. Enteral refeeding is useful for promoting growth in neonates with enterostomy before stoma closure. J Pediatr Surg. 2016 Mar;51(3):390-4.
  8. Yamaguchi T, Ishida H, Ueno H, Kobayashi H, Hinoi T, Inoue Y, Ishida F, Kanemitsu Y, Konishi T, Tomita N, Matsubara N, Watanabe T, Sugihara K. Upper gastrointestinal tumours in Japanese familial adenomatous polyposis patients. Jpn J Clin Oncol. 2016 Apr;46(4):310-5.
  9. Koi M, Garcia M, Choi C, Kim HR, Koike J, Hemmi H, Nagasaka T, Okugawa Y, Toiyama Y, Kitajima T, Imaoka H, Kusunoki M, Chen YH, Mukherjee B, Boland CR, Carethers JM. Microsatellite Alterations With Allelic Loss at 9p24.2 Signify Less-Aggressive Colorectal Cancer Metastasis. Gastroenterology. 2016 Apr;150(4):944-55.
  10. Saigusa S, Toiyama Y, Tanaka K, Inoue Y, Mori K, Ide S, Imaoka H, Kawamura M, Mohri Y, Kusunoki M. Prognostic relevance of stromal CD26 expression in rectal cancer after chemoradiotherapy. Int J Clin Oncol. 2016 Apr;21(2):350-8.
  11. Okigami M,Tanaka K,Inoue Y, Saigusa S, Okugawa Y, Toiyama Y,Mohri Y, Kusunoki M.Intravital imaging of the effects of 5-fluorouracil on the murine liver microenvironment using 2-photon laser scanning microscopy.Oncol Lett. 2016 Apr;11(4):2433-2439.
  12. Noguchi T, Toiyama Y, Kitajima T, Imaoka H, Hiro J, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Toden S, Kusunoki M. MicroRNA-503 promotes tumor progression and associates with early recurrence and poor prognosis in human colorectal cancer. Oncology. 2016;90(4):221-31.
  13. Kato H, Usui M, Iizawa Y, Tanemura A, Murata Y, Kuriyama N, Kishiwada M, Mizuno S, Sakurai H, Inoue M, Uchida K, Isaji S. Living Donor Liver Transplantation for Biliary Atresia With Severe Preduodenal Portal Vein Stricture: Success and Pitfall of Portal Vein Reconstruction. Transplant Proc. 2016 May;48(4):1218-20.
  14. Araki T, Okita Y, Kawamura M, Kondo S, Kobayashi M, Ohi M, Toiyama Y, Tanaka K, Inoue Y, Uchida K, Mohri Y, Kusunoki M. Endoscopy-Assisted Transanal Repair of Afferent-Limb Obstruction and Long Efferent Limb with Ileopexy after Ileal J-Pouch-anal anastomosis. Asian J Endosc Surg. 2016 May;9(2):167-9.
  15. Inoue Y,Saigusa S,Hiro J,Toiyama Y,Araki T,Tanaka K,Mohri Y,Kusunoki M: Clinical significance of enlarged lateral pelvic lymph nodes before and after preoperative chemoradiotherapy for rectal cancer. Mol Clin Oncol. 2016 Jun;4(6):994-1002.
  16. Oki S, Inoue M, Otake K, Matsushita K, Uchida K, Koike Y, Kusunoki M．Laparoscopic Repair of Bladder Rupture in a Neonate．International J Urology　 Int J Urol. 2016 Jun;23(6):520-522.
  17. Higashi D, Katsuno H, Kimura H, Takahashi K, Ikeuchi H, Kono T, Nezu R, Hatakeyama K, Kameyama H, Sasaki I, Fukushima K, Watanabe K, Kusunoki M, Araki T, Maeda K, Kameoka S, Itabashi M, Nakao S, Maeda K, Ohge H, Watadani Y, Watanabe T, Sunami E, Hotokezaka M, Sugita A, Funayama Y, Futami K.Current State of and Problems Related to Cancer of the Intestinal Tract Associated with Crohn’s Disease in Japan.　Anticancer Res. 2016 Jul;36(7):3761-6.
  18. Matsuda T, Kurokawa Y, Yoshikawa T, Kishi K, Misawa K, Ohi M, Mine S, Hiki N, Takeuchi H. Clinicopathological Characteristics and Prognostic Factors of Patients with Siewert Type II Esophagogastric Junction Carcinoma: A Retrospective Multicenter Study. World J Surg. 2016 Jul;40(7):1672-9.
  19. Okita Y, Araki T, Uchida K, Matsushita K, Kawamura M, Koike Y, Otake K, Inoue M, Toiyama Y, Ohi M, Tanaka K, Inoue Y, Kusunoki M.Secondary pouchitis in a pediatric patient successfully treated by salvage surgery　 Pediatr Int. 2016 Jul;58(7):625-8.
  20. Imaoka H, Toiyama Y, Okigami M, Yasuda H, Saigusa S, Ohi M, Tanaka K, Inoue Y, Mohri Y, Kusunoki M. Circulating microRNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer. Gastric Cancer. 2016 Jul;19(3):744-753.
  21. Ueno H, Kobayashi H, Konishi T, Ishida F, Yamaguchi T, Hinoi T, Kanemitsu Y, Inoue Y, Tomita N, Matsubara N, Komori K, Ozawa H, Nagasaka T, Hasegawa H, Koyama　M, Akagi Y, Yatsuoka T, Kumamoto K, Kurachi K, Tanakaya K, Yoshimatsu K, Watanabe　T, Sugihara K, Ishida H. Prevalence of laparoscopic surgical treatment and its　clinical outcomes in patients with familial adenomatous polyposis in Japan. Int J Clin Oncol. 2016 Aug;21(4):713-22.
  22. Saito Y, Hinoi T, Ueno H, Kobayashi H, Konishi T, Ishida F, Yamaguchi T, Inoue　Y, Kanemitsu Y, Tomita N, Matsubara N, Komori K, Kotake K, Nagasaka T, Hasegawa　H, Koyama M, Ohdan H, Watanabe T, Sugihara K, Ishida H. Risk Factors for the　Development of Desmoid Tumor After Colectomy in Patients with Familial　Adenomatous Polyposis: Multicenter Retrospective Cohort Study in Japan. Ann Surg Oncol. 2016 Aug;23(Suppl 4):559-565.
  23. Inoue Y, Ishida H, Ueno H, Kobayashi H, Yamaguchi T, Konishi T, Tomita N, Matsubara N, Ishida F, Hinoi T, Kanemitsu Y, Watanabe T, Sugihara K.　Therapeutic approaches for patients with coexisting familial adenomatous polyposis and colorectal cancer.　 Jpn J Clin Oncol. 2016 Sep;46(9):819-24.
  24. Yokoyama K, Hatanaka H, Inoue M, Yano T, Numao N, Ushio J, Lefor AK, Tamada K, Yamamoto H. Multiple orifices and cholangiography with a “fire-like” appearance after Kasai hepatoportoenterostomy for biliary atresia.J Pediatr Surg. 2016 Sep;51(9):1574-6.
  25. Shi C, Yang Y, Xia Y, Okugawa Y, Yang J, Liang Y, Chen H, Zhang P, Wang F, Han H, Wu W, Gao R, Gasche C, Qin H, Ma Y, Goel A.Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer.Gut. 2016 Sep;65(9):1470-81.
  26. Okugawa Y, Toiyama Y, Mohri Y,Tanaka K, Kawamura M, Kitajima T, Shimura T, Imaoka H,Saigusa S,Tanaka M, Inoue Y,Uchida K,Miki　C,Kusunoki　M.　Elevated serum concentration of monocyte chemotactic protein 4 (MCP-4) as a novel non-invasive prognostic and predictive biomarker for detection of metastasis in colorectal cancerJ Surg Oncol. 2016 Sep;114(4):483-9.
  27. Okita Y, Araki T, Kawamura M, Kondo S, Inoue M, Kobayashi M, Toiyama Y, Ohi M, Tanaka K, Inoue Y, Uchida K, Mohri Y, Kusunoki M. Clinical features and management of afferent limb syndrome after ileal pouch-anal anastomosis for ulcerative colitis. Surg Today. 2016 Oct;46(10):1159-65.
  28. Weng W, Okugawa Y, Toden S, Toiyama Y, Kusunoki M, Goel A.　FOXM1 and FOXQ1 Are Promising Prognostic Biomarkers and Novel Targets of Tumor-Suppressive miR-342 in Human Colorectal Cancer.　 Clin Cancer Res. 2016 Oct 1;22(19):4947-4957.
  29. Konishi T, Ishida H, Ueno H, Kobayashi H, Hinoi T, Inoue Y, Ishida F, Kanemitsu Y, Yamaguchi T, Tomita N, Matsubara N, Watanabe T, Sugihara K. Feasibility of laparoscopic total proctocolectomy with ileal pouch-anal anastomosis and total colectomy with ileorectal anastomosis for familial adenomatous polyposis: results of a nationwide multicenter study Int J Clin Oncol. 2016 Oct;21(5):953-961.
  30. Okugawa Y, Mohri Y, Tanaka K, Kawamura K, Saigusa S, Toiyama Y, Ohi M, Inoue Y, Kusunoki M. Metastasis-associated protein (MTA) is a predictive biomarker for metastasis and recurrence in gastric cancer. Oncol Rep 2016; 36(4): 1893-1900.
  31. Saigusa S, Toiyama Y, Tanaka K, Inoue Y, Mori K, Ide S, Imaoka H, Kawamura M, Mohri Y, Kusunoki M. Implication of programmed cell death ligand 1 expression in tumor recurrence and prognosis in rectal cancer with neoadjuvant chemoradiotherapy. Int J Clin Oncol. 2016 Oct;21(5):946-952.
  32. Imaoka　H, Toiyama　Y, Fujikawa　H, Hiro　J, Saigusa　S, Tanaka　K, Inoue　Y, Mohri Y, Mori T, Kato T,Goel A ,Kusunoki M.Circulating microRNA-1290 as a novel diagnostic and prognostic biomarker in human colorectal cancer.Ann Oncol. 2016 Oct;27(10):1879-86.
  33. Uratani R, Toiyama Y, Kitajima T, Kawamura M, Hiro J, Kobayashi M, Tanaka K, Inoue Y, Mohri Y, Mori T, Kato T, Goel A, Kusunoki M. Diagnostic potential of circulating and exosomal microRNAs in the identification of patients with high-risk colorectal adenomas. PLoS One. 2016 Oct 19;11(10):e0160722.
  34. Ohtsuka M, Ling H, Ivan C, Pichler M, Matsushita D, Goblirsch M, Stiegelbauer V, Shigeyasu K, Zhang X, Chen M, Vidhu F, Bartholomeusz GA, Toiyama Y, Kusunoki M, Doki Y, Mori M, Song S, Gunther JR, Krishnan S, Slaby O, Goel A, Ajani JA, Radovich M, Calin GA. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer. EBioMedicine. 2016 Nov;13:113-124.
  35. Yasuda H, Shimura T, Okigami M, Ohi M, Tanaka K, Mohri Y, Kusunoki M. Esophageal Cancer with Bone Marrow Hyperplasia Mimicking Bone Metastasis: Report of a Case. Case Rep Oncol. 2016 Nov 7;9:679–684.
  36. Mohri Y, Toiyama Y, Kusunoki M. Progress and prospects for the discovery of biomarkers for gastric cancer: a focus on proteomics. Expert Rev Proteomics. 2016 Dec;13(12):1131-1139.
  37. Uchida K, Okita Y, Araki T, Kusunoki M. Pouchitis in Pediatric Ulcerative Colitis Patients After Ileal Pouch Anal Anastomosis. J Pediatr Gastroenterol Nutr. 2016 Dec;63(6):e211.
  38. Toiyama Y, Hiro J, Shimura T, Fujikawa H, Ohi M, Tanaka K, Inoue Y, Mohri Y, Kusunoki M.The impact of body mass index on oncological outcomes in colorectal cancer patients with curative intent. Int J Clin Oncol. 2016 Dec;21(6):1102-1110.
  39. Toiyama Y, Shimura T, Yasuda H, Fujikawa H, Okita Y, Kobayashi M, Ohi M, Yoshiyama S, Hiro J, Araki T, Inoue Y, Mohri Y, Kusunoki M. Clinical Burden of C-Reactive Protein/Albumin Ratio Before Curative Surgery for Patients with Gastric Cancer. Anticancer Res. 2016 Dec;36(12):6491-6498
  40. Miyake H, Chen Y, Koike Y, Hock A, Li B, Lee C, Zani A, Pierro A. Osmolality of enteral formula and severity of experimental necrotizing enterocolitis. Pediatr Surg Int. 2016 Dec;32(12):1153-1156.
  41. Chen Y, Koike Y, Miyake H, Li B, Lee C, Hock A, Zani A, Pierro A. Formula feeding and systemic hypoxia synergistically induce intestinal hypoxia in experimental necrotizing enterocolitis. Pediatr Surg Int. 2016 Dec;32(12):1115-1119.
  42. Kawamura M, Araki T, Okita Y, Kondo S, Ichikawa T, Fujikawa H, Uchida K, Mohri Y, Kusunoki M. Spinal epidural abscess: a rare complication of ulcerative colitis after ileal pouch anal anastomosis. Surg Case Rep. 2016 Dec;2(1):128.
  43. Nagano Y, Toiyama Y, Okugawa Y, Imaoka H, Fujikawa H, Yasuda H, Yoshiyama S, Hiro J, Kobayashi M, Ohi M, Araki T, Inoue Y, Mohri Y, Kusunoki M. MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer. Anticancer Res. 2016 Dec;36(12):6521-6526.

Non-Pub-Med

  1. Kusunoki M: Colitis-Associated Cancer: Overview: Kusunoki M (eds), Colitis-Associated Cancer, Springer Japan, P1-19, 2016.
  2. Tanaka K, Araki T, Toiyama Y, Okita Y, Mohri Y, Kusunoki M: Incidence and Risk Factors : Kusunoki M (eds), Colitis-Associated Cancer, Springer Japan, P23-39, 2016.
  3. Okita Y, Araki T, Tanaka K, Toiyama Y, Uchida K, Kusunoki M: Cancer Surveillance of Patients with Long-Standing Inflammatory Bowel Disease: Kusunoki M (eds), Colitis-Associated Cancer, Springer Japan, P61-83, 2016.
  4. Toiyama Y, Araki T, Tanaka K, Mohri Y, Kusunoki M: Molecular Alterations in Inflammatory Colonic Carcinogenesis and Markers for Detecting Colitis-Associated Cancer: Kusunoki M (eds), Colitis-Associated Cancer, Springer Japan, P85-105, 2016.
  5. Araki T, Toiyama Y, Okita Y, Tanaka K, Inoue Y, Uchida K, Mohri Y, Kusunoki M: Surgical Treatment for Ulcerative Colitis-Associated Cancer or Dysplasia: Kusunoki M (eds), Colitis-Associated Cancer, Springer Japan, P109-130, 2016.
  6. Murata Y, Mizuno S, Otake K, Inoue M, Uchida K, Honma H, Toyoda H, Komada Y, Fukutome K, Isaji S.Spleen-preserving distal pancreatectomy with the Warshaw technique after chemotherapy for initially unresectable pancreatoblastoma in a 3-year-old girl, paying attention to long-term change in spleen volume and venous collaterals.J Pancreas(Online)2016 Mar 07;17(2):230-236.
  7. Uchida K, Koike Y, Inoue M, Otake K, Matsushita K, Hashimoto K, Nagano Y, Okita Y, Kawamura M, Toiyama Y, Kobayashi M, Araki T, Mohri Y, Kusunoki M. Impact of preoperative medical therapy for surgical site infection in children with ulcerative colitis: a single-center experience. SM Group e Books “Inflammatory bowel Disease　2016　May 10.
  8. Tanaka K, Araki T, Yoshiyama S, Okita Y, Kondo S, Toiyama Y, Inoue M, Ohi M, Kobayashi M, Inoue Y, Uchida K, Mohri Y, Miki C, Kusunoki M. Leukocytapheresis changes functional characteristics of circulating neutrophils in human: the mechanistic implications.International Journal of Digestive Diseases.2016 2(1):17.
  9. Otake K, Uchida K, Nagano Y, Noguchi T, Shimura T, Matsushita K, Inoue M, Kusunoki M.Drip infusion cholangiography with computed tomography in the evaluation of bile leakage after blunt liver trauma in children: two case reports Pediatric Emergency Care and Medicine:Open Access. 2016;1:1(3).

和文業績

著書

  1. 小林美奈子：第3章抗菌薬と耐性菌,森兼啓太（編）,外科医のためのインフェクションコントロール, １版１刷，中外医学社，東京,82－111,2016

総説

  1. 荒木俊光,廣純一郎,大北喜基,川村幹雄,藤川裕之,問山裕二,井上靖浩,内田恵一,楠　正人：腹腔鏡下全大腸切除・回腸嚢肛門吻合術.臨床外科,71(2)：188-194,2016
  2. 荒木俊光,大北喜基,廣　純一郎,問山裕二,井上靖浩,毛利靖彦,楠　正人：特集　消化器癌におけるバイパス術とステント治療　Ⅱ.臓器別各論　3.大腸　１）大腸狭窄に対するバイパス術・ストーマ造設術など.外科,78(10)：1065-1069,2016
  3. 小林美奈子,楠　正人：〈総説〉術後感染予防抗菌薬の適正使用.環境感染誌,31(2)：87-91,2016
  4. 小林美奈子,楠　正人：特集　抗菌薬の考え方,使い方ホントのところを聞いてみました
    腹腔内感染症　腹膜炎.medicina, 53(7)：1030-1032,2016
  5. 小林美奈子：06floor　周術期感染防止．INFECTION CONTROL 2016 春季増刊,104-115,2016
  6. 小林美奈子,大井正貴,大北喜基,井上幹大,問山裕二,田中光司,井上靖浩,荒木俊光,毛利靖彦,楠　正人：特集：予防抗菌薬　総説　術後感染予防薬の標準的使用と本邦での変遷.日本外科感染症学会雑誌,13(4)：273-277,2016
  7. 問山裕二,楠　正人：特集：大腸癌　update Ⅵ．大腸癌検診の動向　分子生物学的アプローチによる新たな大腸癌検診.日本臨床,74(11)：1895-1901,2016
  8. 問山裕二,井上靖浩,楠　正人：特集　主題Ⅰ：大腸癌診断の最前線　Ⅴ.分子生物学的手法による大腸癌診断．日本大腸肛門病学会雑誌,69(10)：480-488,2016
  9. 井上幹大,長野由佳,松下航平,大竹耕平,内田恵一：特集　小児内視鏡手術：脾摘および縫合による技術審査に向けて 横隔膜ヘルニア：胸腔鏡下縫合法.小児外科,48(4)：388-390,2016
  10. 廣　純一郎,楠　正人：【どれを選ぶのがベスト?教えて先生!迷った時の内視鏡外科手術器械・デバイスおたすけファイル】 こんな時何を使う?　剥離鉗子のベストチョイス.オペナーシング,31(8) :804-807,2016
  11. 廣　純一郎,楠　正人：特集：進行大腸癌に対する内視鏡外科手術の限界　Ⅱ．各論　7.肝転移，肺転移，腹膜播種を伴う大腸癌に対する内視鏡外科手術．臨床雑誌「外科」,78(3)：273-278,2016
  12. 大北喜基,荒木俊光,楠　正人：【もっと知りたい特集5】これも知りたい術式イラスト便利帳　大腸全摘・Ｊ型回腸嚢肛門吻合術.消化器外科NURSING,21(1)：74-75,2016
  13. 大竹耕平：【特集　消化器内科領域で漢方薬を活用する】解説　乳児胃食道逆流症（GERD）の嘔吐症状．Science of Kampo Medicine 漢方医学,40(3)：32-35,2016
  14. 沖上正人,井上靖浩,毛利靖彦,楠　正人：【そのまま使える!「こう説明しよう!」シートつき　消化器がん化学療法の患者指導】 大腸がんの化学療法(解説/特集)
    消化器外科Nursing ,21(8) :691-700,2016
  15. 沖　哲,井上靖浩,毛利靖彦,楠　正人：3章　大腸切除術の再建法　特集6　再建法の違いから術式をもっと理解する！　再建後のカラダ　大解剖　直腸切断術．消化器外科NURSING,21(11)：991-995,2016
  16. 新　英里,出口真利,逵村真理子,林　智世,荒木俊光,井上靖浩,毛利靖彦,楠　正人：特別企画Vacuum Assisted Closure®療法と看護ケア．消化器外科NURSING,21(9)：841-847,2016

症例報告

  1. 三枝　晋,大井正貴,今岡裕基,浦谷　亮,小林美奈子,井上靖浩.開窓術後早期
    vacuum assisted closure療法により閉鎖した難治性膿胸の1例.日本臨床外科学会雑誌、77(8):1927-1931,2016

その他

  1. 荒木俊光：IBDに対する腹腔鏡手術のメリット・デメリット.　IBDニュース(CCFJ) vol. 58. P2,2016
  2. 小林美奈子：【ケーススタディ・第38回抗菌薬適正使用生涯教育セミナー　】術後感染症．日本化学療法学会雑誌,64(5)：755-759,2016