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研究紹介

2014年 研究業績

英文業績

Pub-Med

  1. Inoue Y, Kusunoki M. Advances and directions in chemotherapy using implantable port systems for colorectal cancer: a historical review. Surg Today. 2014;44(8):1406-1414.
  2. Inoue Y, Toiyama Y, Tanaka K, Mohri Y, Kusunoki M. Consideration of therapeutic approach to advanced colorectal cancer in elderly patients. International Journal of Cancer Therapy and Oncology.2014;2(1):02014.
  3. Saigusa S, Inoue Y, Tanaka K, Okugawa Y, Toiyama Y, Uchida K, Mohri Y, Kusunoki M. Lack of M30 expression correlates with factors reflecting tumor progression in rectal cancer with preoperative chemoradiotherapy. Mol Clin Oncol. 2014;2(1):99-104.
  4. Yoshida K, Araki T, Uchida K, Okita Y, Fujikawa H, Inoue M, Tanaka K, Inoue Y, Mohri Y, Kusunoki M. Sexual activity after ileal pouch-anal anastomosis in Japanese patients with ulcerative colitis. Surg Today.2014 Jan;44(1):73-9.
  5. Watanabe K, Sasaki I, Fukushima K, Futami K, Ikeuchi H, Sugita A, Nezu R, Mizushima T, Kameoka S, Kusunoki M, Yoshioka K, Funayama Y, Watanabe T, Fujii H, Watanabe M. Long-term incidence and characteristics of intestinal failure in Crohn’s disease: a multicenter study. J Gastroenterol. 2014Feb;49(2):231-8.
  6. Inoue Y, Araki T, Okugawa Y, Kawamoto A, Hiro J, Toiyama Y, Tanaka K, Uchida K, Mohri Y, Kusunoki M. Chemoradiotherapy followed by restorative proctocolectomy with partial intersphincteric resection for advanced rectal cancer associated with ulcerative colitis: report of a case. Surg Today. 2014 Feb;44(2):387-90.
  7. Tanaka K, Kawamura M, Otake K, Toiyama Y, Okugawa Y, Inoue Y, Uchida K, Araki T, Mohri Y, Kusunoki M. Trehalose does not affect the functions of human neutrophils in vitro. Surg Today. 2014 Feb;44(2):332-9.
  8. Araki T, Uchida K, Okita Y, Fujikawa H, Inoue M, Ohi M, Tanaka K, Inoue Y, Mohri Y, Kusunoki M. Impact of postoperative infliximab maintenance therapy on preventing the surgical recurrence of Crohn’s disease: a single-center paired case-control study. Surg Today. 2014 Feb;44(2) :291-6.
  9. Mohri Y, Miki C, Kobayashi M, Okita Y, Inoue M, Uchida K, Tanaka K, Inoue Y, Kusunoki M. Correlation between preoperative systemic inflammation and postoperative infection in patients with gastrointestinal cancer: a multicenter study. Surg Today. 2014;44(5):859-867.
  10. Kobayashi M, Mohri Y, Ohi M, Inoue Y, Araki T, Okita Y, Kusunoki M. Risk factors for anastomotic leakage and favorable antimicrobial treatment as empirical therapy for intra-abdominal infection in patients undergoing colorectal surgery. Surg Today. 2014 Mar;44(3):487-93.
  11. Toiyama Y, Boland CR, Goel A. Response. J Natl Cancer Inst. 2014 Mar;106(3):djt458. doi
  12. Hiro J, Inoue Y, Okugawa Y, Kawamoto A, Okita Y, Toiyama Y, Tanaka K, Uchida K, Mohri Y, Kusunoki M. Single-port laparoscopic management of adhesive small bowel obstruction. Surg Today. 2014 Mar;44(3):586-90.
  13. Tanaka K, Araki T, Okita Y, Fujikawa H, Kawamura M, Uchida K, Mohri Y, Kusunoki M. Pyoderma gangrenosum occurring at the peri-ileal pouch-anal anastomosis in a patient with ulcerative colitis: report of a case. Surg Today. 2014 Apr;44(4):783-5.
  14. Toiyama Y, Hur K, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A. Serum miR-200c Is a Novel Prognostic and Metastasis-Predictive Biomarker in Patients With Colorectal Cancer. Ann Surg. 2014 Apr;259(4):735-43.
  15. Saigusa S, Mohri Y, Tanaka K, Ohi M, Shimura T, Kitajima T, Ishino Y, Yasuda H, Okugawa Y, Toiyama Y, Inoue Y, Uchida K, Kusunoki M. Impact of extracapsular lymph node involvement on tumor progression in esophageal squamous cell carcinoma after neoadjuvant therapy and effects on lymph nodes induced by chemotherapy and chemoradiotherapy. Esophagus 2014;11:108-116.
  16. Tanaka K, Okugawa Y, Toiyama Y, Inoue Y, Saigusa S, Kawamura M, Araki T, Uchida K, Mohri Y, Kusunoki M. Brain-Derived Neurotrophic Factor (BDNF)-Induced Tropomyosin-Related Kinase B (Trk B) Signaling Is a Potential Therapeutic Target for Peritoneal Carcinomatosis Arising from Colorectal Cancer. PLoS One. 2014 May 6;9(5):e96410.
  17. Tanaka K, Toiyama Y, Okugawa Y, Okigami M, Inoue Y, Uchida K, Araki T, Mohri Y, Mizoguchi A, Kusunoki M. In vivo optical imaging of cancer metastasis using multiphoton microscopy: a short review. Am J Transl Res. 2014 May 15;6(3):179-87.
  18. Iwasa T, Ohashi H, Kihira K, Koike Y, Otake K, Inoue M, Sawada H, Toyoda H, Komada Y. 10-year-old girl with life-threatening idiopathic systemic capillary leak syndrome: a case report. BMC Pediatr. 2014 May 31;14:137.
  19. Saigusa S, Ohi M, Imaoka H, Shimura T, Inoue Y, Kusunoki M. Intussusception of rectosigmoid colon cancer mimicking a pedunculated tumor. Case Rep Surg. 2014;696403.
  20. Saigusa S, Tanaka K, Inoue Y, Toiyama Y, Okugawa Y, Iwata T, Mohri Y, Kusunoki M. Low serum interleukin-13 levels correlate with poorer prognoses for colorectal cancer patients. Int Surg. 2014 May-Jun;99(3):223-9.
  21. Mohri Y, Tanaka K, Ohi M, Saigusa S, Yasuda H, Toiyama Y, Araki T, Inoue Y, Kusunoki M. Identification of prognostic factors and surgical indications for metastatic gastric cancer. BMC Cancer. 2014 14:409.
  22. Toyoda H, Hirayama J, Sugimoto Y, Uchida K, Ohishi K, Hirayama M, Komada Y. Polycythemia and Paraganglioma With a Novel Somatic HIF2A Mutation in a Male. Pediatrics. 2014 133(6):e1787-1791.
  23. Tanaka K, Shimura T, Kitajima T, Kondo S, Ide S, Okugawa Y, Saigusa S, Toiyama Y, Inoue Y, Araki T, Uchida K, Mohri Y, Kusunoki M. Tropomyosin-related receptor kinase B at the invasive front and tumour cell dedifferentiation in gastric cancer. Br J Cancer. 2014 110(12):2923-2934.
  24. Araki T, Okita Y, Uchino M, Ikeuchi H, Sasaki I, Funayama Y, Fukushima K, Futami K, Maeda K, Iiai T, Itabashi M, Hase K, Motoya S, Kitano A, Mizushima T, Maeda K, Kobayashi M, Mohri Y, Kusunoki M. Risk factors for surgical site infection in Japanese patients with ulcerative colitis: a multicenter prospective study. Surg Today. 2014 Jun;44(6):1072-8.
  25. Koike Y, Uchida K, Inoue M, Ide S, Hashimoto K, Matsushita K, Otake K, Ohkita Y, Araki T, Kobayashi M, Mohri Y, Kusunoki M. Infantile Crohn’s disease is one of the risk factors for catheter-related bloodstream infection. Pediatr Int. 2014 Jun;56(3):364-8. doi: 10.1111/ped.12304.
  26. Uchida K, Araki T, Hashimoto K, Inoue M, Otake K, Koike Y, Okita Y, Fujikawa H, Tanaka K, Mohri Y, Kusunoki M. Segmental Distribution in Refractory Ulcerative Colitis: A Histological Evaluation in Pediatric and Adult Patients Who Underwent Proctocolectomy. Inflamm Bowel Dis. 2014 20(7):1227-1235.
  27. Koike Y, Uchida K, Matsushita K, Otake K, Nakazawa M, Inoue M, Kusunoki M, Tsukamoto Y. Intraluminal appendiceal fluid is a predictive factor for recurrent appendicitis after initial successful non-operative management of uncomplicated appendicitis in pediatric patients. J Pediatr Surg. 2014 Jul;49(7):1116-21.
  28. Kawamura M, Tanaka K, Toiyama Y, Okugawa Y, Okigami M, Yasuda H, Saigusa S, Ohi M, Inoue Y, Uchida K, Mohri Y, Kusunoki M. Clinical Significance of Tartrate-resistant Acid Phosphatase Type-5 Expression in Human Gastric Cancer. Anticancer Res. 2014 Jul;34(7):3425-9.
  29. Araki T, Okita Y, Fujikawa H, Uchida K, Mohri Y, Kusunoki M. Functional and Manometric Outcomes after Redo-Ileal Pouch Anal Anastomosis in Patients with Ulcerative Colitis. Dig Surg. 2014 Aug 28;31(3):190-196.
  30. Perez-Carbonell L, Balaguer F, Toiyama Y, Egoavil C, Rojas E, Guarinos C, Andreu M, Llor X, Castells A, Jover R, Boland CR, Goel A. IGFBP3 methylation is a novel diagnostic and predictive marker in colorectal cancer. Plos one 2014 Aug 15;9(8):e104285.
  31. Otake K, Uchida K, Inoue M, Koike Y, Noguchi T, Miyamoto N, Sudo A, Kusunoki M. Staged management of pseudoexstrophy with omphalocele and wide pubic diastasis . JPS case reports. 2014;2(8):388–390.
  32. Okugawa Y, Toiyama Y, Goal A. An update on microRNAs as colorectal cancer biomarkers: where are we and what’s next? Expert Rev Mol Diagn. 2014 Aug 28:1-23.
  33. Saigusa S, Ohi M, Imaoka H, Shimura T, Uratani R, Inoue Y, Kusunoki M. Unawareness of a prolonged retained capsule endoscopy: the importance of careful follow-up and cooperation between medical institutions. Case Rep in Gastrointest Med. 2014:909360.
  34. Fukata N, Okazaki K, Omiya M, Matsushita M, Watanabe M. Hematologic malignancies in the Japanese patients with inflammatory bowel disease. J Gastroenterol. 2014　Sep;49(9):1299-306.
  35. Araki T, OkitaY, Fujikawa H, Ohi M, Tanaka K, Inoue Y, Uchida K, Mohri Y, Kusunoki M. Redo-lleal pouch-anal anastomosis combined with anti-TNF-α maintenance therapy for Crohn’s disease with pelvic fistula: Report of two cases. Surgery Today. 2014;44(10):1982-1985.
  36. Kitajima T, Toiyama Y, Tanaka K., Saigusa S, Kobayashi M, Inoue Y, Mohri Y, Kusunoki M. Vasohibin-1 increases the malignant potential of colorectal cancer and is a biomarker of poor prognosis. Anticancer Res. 2014;34(10):6321-5329.
  37. Ohfuji S, Fukushima W, Watanabe K, Sasaki S, Yamagami H, Nagahori M, Watanabe M, Hirota Y; Japanese Case-Control Study Group for Ulcerative Colitis. Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan. PLoS One. 2014 Oct 14;9(10):e110270.
  38. Ishikawa H, Mutoh M, Suzuki S, Tokudome S, Saida Y, Abe T, Okamura S, Tajika M, Joh T, Tanaka S, Kudo SE, Matsuda T, Iimuro M, Yukawa T, Takayama T, Sato Y, Lee K, Kitamura S, Mizuno M, Sano Y, Gondo N, Sugimoto K, Kusunoki M, Goto C, Matsuura N, Sakai T, Wakabayashi K. The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial. Gut. 2014; 63(11):1755-1759.
  39. Tanaka K, Koike Y, Matsushita K, Okigami M, Toiyama Y, Kawamura M, Saigusa S, Okugawa Y, Inoue Y, Uchida K, Araki T, Mohri Y, Mizoguchi A, Kusunoki M. In vivo characterization of neutrophil extracellular traps in various organs of a murine sepsis model. PLOS ONE. 2014;9(11):e111888.
  40. Ishino Y, Saigusa S, Ohi M, Yasuda H, Tanaka K, Toiyama Y, Mohri Y, Kusunoki M. Preoperative C-reactive protein and operative blood loss predict poor prognosis in patients with gastric cancer after laparoscopy-assisted gastrectomy. Asian J Endosc Surg. 2014;7(4):287-294.
  41. Toiyama Y, Inoue Y, Kitajima T, Okigami M, Kawamura M, Kawamoto A, Okugawa Y , Hiro J, Tanaka K, Mohri Y, Kusunoki M. Conversion therapy using mFOLFOX6 with Panitumumab for unresectable liver metastases from multiple colorectal cancers with FAP. Int Surg. 2014 November-December;99(6):795-801.
  42. Kawamoto A, Inoue Y, Okigami M, Okugawa Y, Hiro J, Toiyama Y, Tanaka K, Uchida K, Mohri Y, Kusunoki M. Puborectal Sling Interposition and Seton Drainage for Rectovaginal Fistula after Rectal Cancer Surgery with Colonic J pouch-Anal Reconstruction. Int Surg. 2014 Nov-Dec;99(6):710-3.
  43. Fujikawa H, Araki T, Hashimoto K, Okita Y, Tanaka K, Hiro J, Inoue Y, Mohri Y, Uchida K, Kusunoki M. Sphincter-saving resection of rectal hemangioma based on Doppler transrectal ultrasonography findings: report of a case. Int Surg. 2014 November-December;99(6):705-709.
  44. Sugimachi K, Niida A, Yamamoto K, Shimamura T, Imoto S, Iinuma H, Shinden Y, Eguchi H, Sudo T, Watanabe M, Tanaka J, Kudo S, Hase K, Kusunoki M, Yamada K, Shimada Y, Sugihara K, Maehara Y, Miyano S, Mori M, Mimori K. Allelic Imbalance at an 8q24 Oncogenic SNP is Involved in Activating MYC in Human Colorectal Cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:515-21.
  45. Toiyama Y, Tanaka K, Kitajima T, Shimura T, Kawamura M, Kawamoto A, Okugawa Y, Saigusa S, Hiro J, Inoue Y, Mohri Y, Goel A, Kusunoki M. Elevated serum angiopoietin-like protein 2 correlates with the metastatic properties of colorectal cancer: a serum biomarker for early diagnosis and recurrence. Clin Cancer Res. 2014 20(23); 1–12.
  46. Toiyama Y, Okugawa Y, Goel A. DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer. Biochem Biophys Res Commun. 2014 Dec 5;455(1-2):43-57.
  47. Okugawa Y, Toiyama Y, Hur K, Toden S, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Kusunoki M, Boland CR, Goel A. Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis. Carcinogenesis. 2014 Dec;35(12):2731-9.
  48. Koike Y, Uchida K, Tanaka K, Ide S, Otake K, Okita Y, Inoue M, Araki T, Mizoguchi A, Kusunoki M. Dynamic pathology for circulating free DNA in a dextran sodium sulfate colitis mouse model. Pediatr Surg Int. 2014 Dec;30(12):1199-206.

Non-Pub-Med

  1. Tanaka K, Mohri Y, Koike Y, Okugawa Y, Toiyama Y, Ohi M, Kobayashi M, Inoue Y, Araki T, Uchida K, Miki C, Kusunoki M. Molecular characteristics of residual cancer and stromal cells after chemoradiotherapy for gastric cancer: report of four cases. Clinical Case Reports. 2014;2(5):165-172.
  2. Kawamura M, Toiyama Y, Tanaka K, Inoue Y, Mohri Y, Kusunoki M. Can　Circulating MicroRNAｓ Become the Test of Choice for Colorectal Cancer? Current colorectal cancer report 2014;10(4):403-410.

和文業績

著書

  1. 荒木俊光，大北喜基，藤川裕之，内田恵一，毛利靖彦，楠　正人：2．各診療の最適化とコツ ２-３　外科治療の術式と適応.2－3－2　クローン病．渡辺　守（総編），久松理一，渡辺憲治（編者），現場のエキスパートが教える実践！IBD診療，医学出版，東京，168-172，2014
  2. 荒木俊光，井上靖浩，毛利靖彦，楠　正人：第4章　がん患者の輸液・栄養療法の進め方とマネジメント　　Ⅱ　合併症を有する際の輸液・栄養管理　3．ステロイド長期症例の周術期栄養管理．大村健二（編），がん患者の輸液・栄養療法，南山堂，東京，166-172，2014
  3. 小林美奈子，楠　正人：各論　１４．その他　～重炭酸治療，深部静脈血栓予防，ストレス潰瘍予防～．竹末芳生（編），肺血症（セプシス）救命治療の最前線，医薬ジャーナル社，東京・大阪，209-212，2014
  4. 小林美奈子，楠　正人：消化管疾患　Ⅳ-13　痔疾患．門脇　孝，小室一成，宮地良樹（監），診療ガイドライン UP-TO-DATE 2014-2015，メディカカルレビュー社，東京・大阪，277-281，2014
  5. 廣　純一郎，井上靖浩，毛利靖彦，楠　正人：第1部臓器別ケア編／第4章　大腸1　大腸の全体構造．2　大腸のはたらき．3頻度の多い病変部位．毛利靖彦，楠　正人（編），解剖生理からケアまで網羅！必須事項がサクッとわかる　消化器外科看護まるごと図解ブック，消化器外科NURSING　2014春季増刊，メディカ出版，東京，68-73，2014
  6. 大北喜基，井上靖浩，毛利靖彦，楠　正人：第2部　臓器別ケア編／第4章　大腸6　合併症：手術部位感染．7　合併症：腸閉塞．8　合併症：縫合不全．9　合併症：排便機能低下．10　合併症：排尿機能障害．毛利靖彦，楠　正人（編），解剖生理からケアまで網羅！必須事項がサクッとわかる　消化器外科看護まるごと図解ブック．消化器外科NURSING　2014春季増刊，メディカ出版，東京，87-92，2014
  7. 川本　文，井上靖浩，毛利靖彦，楠　正人：第2部　臓器別ケア編／第4章　大腸4　結腸切除術． 5虫垂切除術．6直腸切除術．7ストーマ造設術．8ストーマケア．9痔核・痔瘻根治術．毛利靖彦，楠　正人（編），解剖生理からケアまで網羅！必須事項がサクッとわかる　消化器外科看護まるごと図解ブック．消化器外科NURSING　2014春季増刊，メディカ出版，東京，74-79，2014
  8. 藤川裕之，井上靖浩，毛利靖彦，楠　正人：第1部　臓器別ケア編／第4章　大腸1　ドレーンの留置部位．2大腸手術後のドレーン管理．3　腸瘻造設．4検査と手術以外の治療．5腸切除後の食事・栄養．毛利靖彦，楠　正人（編），解剖生理からケアまで網羅！必須事項がサクッとわかる　消化器外科看護まるごと図解ブック．消化器外科NURSING　2014春季増刊，メディカ出版，東京，80-86，2014

総説

  1. 堀木紀行，十時利明，北出　卓，葛原正樹，濱田康彦，田中匡介，荒木俊光，楠　正人，竹井謙之：【炎症性腸疾患の画像診断modality】大腸内視鏡　　拡大内視鏡． INTEDTINE，18(2): 119-126，2014
  2. 毛利靖彦，田中光司，楠　正人：最新胃癌学－基礎と臨床の最新研究動向－　Ⅱ胃癌の疫学　胃癌の疫学－国際比較－．日本臨床　最新胃癌学，72（増刊1）：47-53，2014
  3. 毛利靖彦，田中光司，毛利智美，楠　正人：最新胃癌学－基礎と臨床の最新研究動向－　Ⅷ胃癌の検査・診断バイオマーカー　プロテオミクス解析によるMIF,DJ-1．日本臨床　最新胃癌学，72（増刊1）：338-342，2014
  4. 内田恵一，楠　正人：【手術のtips and pitfalls】小児における潰瘍性大腸炎に対する手術のtips and pitfalls．日本外科学会雑誌，115(5): 283-286，2014
  5. 井上靖浩，廣　純一郎，問山裕二，楠　正人：専門医必修！消化器癌定型手術の標準手技アトラス大腸癌　低位前方切除術．手術（臨時増刊号），68(4):623-628，2014
  6. 荒木俊光，大北喜基，藤川裕之，廣　純一郎，問山裕二，田中光司，井上靖浩，内田恵一， 毛利靖彦，楠　正人：特集　ディベート　炎症性腸疾患の外科治療　Ⅰ．潰瘍性大腸炎に対する外科治療　２．回腸肛門吻合VS回腸嚢肛門管吻合　a) 回腸肛門吻合．外科，76(3):240-244，2014
  7. 小林美奈子，楠　正人：特集　これだけは押さえておきたい　感染症診療の常識　４．腹腔内感染症．レジデント，7(8): 32-37，2014
  8. 問山裕二，奥川喜永，田中光司，井上靖浩，毛利靖彦，楠　正人： 【大腸がんの早期発見を目指して】MicroRNAを用いた非侵襲的大腸癌診断の現状と展望．日本消化器病学会雑誌，111(3): 482-494，2014
  9. 問山裕二，楠　正人：【特集　miRNAの実力：診断から治療まで】３．miR-21による大腸がんの早期診断．医薬ジャーナル，50(12): 73-79，2014
  10. 大北喜基，荒木俊光，楠　正人：【特集　Ⅰ．難治性潰瘍性大腸炎の治療戦略】潰瘍性大腸炎における術前治療と術後合併症の関連．消化器内科，58(6): 759-764，2014
  11. 大北喜基，荒木俊光，楠　正人：【潰瘍性大腸炎とクローン病の治療・食事療法のすべて】潰瘍性大腸炎の外科治療． Nutrition Care，7(7): 621-624，2014
  12. 大北喜基，荒木俊光，楠　正人：【潰瘍性大腸炎とクローン病の治療・食事療法のすべて】クローン病の外科治療． Nutrition Care，7(7): 647-651，2014
  13. 藤川裕之，太田章比古，楠　正人：特集　炎症性腸疾患攻略の手引き　これだけは知っておきたい！炎症性腸疾患の治療―いままでの治療・これからの治療　各種薬剤をどのように使用していくのか？【外科治療】肛門部病変の診断と治療　視診，触診は重要！medicina ，51(6)：1088-1091，2014
  14. 小池勇樹，内田恵一，松下航平，大竹耕平，井上幹大，楠　正人：【最近の肥厚性幽門狭窄症】 遺伝子異常と幽門筋の肥厚.小児外科，46(10)：993-995，2014

原著

  1. 荒木俊光，大北喜基，廣　純一郎，問山裕二，大井正貴，田中光司，井上靖浩，毛利靖彦，楠　正人：潰瘍性大腸炎に対する緊急手術術後重篤合併症発生因子の検討．日本腹部救急医学会雑誌，35(4): 929-933，2014
  2. 安田裕美，毛利靖彦，志村匡信，沖上正人，大井正貴，小林美奈子，田中光司，楠　正人：【特集　内視鏡外科手術と術後感染症】胃癌に対する腹腔鏡下胃切除術がSSIに与える影響．日本外科感染症学会雑誌，11(4):295-301，2014

症例報告

  1. 三枝　晋，大井正貴，今岡裕基，志村匡信，井上靖浩，楠　正人：腹腔鏡下手術を施行した回腸狭窄によるカプセル内視鏡滞留の1例．日本臨床外科学会雑誌，75(5):1320-1323，2014