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研究紹介

2012年 研究業績

英文業績

Pub-Med

  1. Kawamoto A, Yokoe T, Tanaka K, Saigusa S, Toiyama Y, Yasuda H, Inoue Y, Miki C, Kusunoki M. Radiation induces epithelial-mesenchymal transition in colorectal cancer cells. Oncol Rep. 2012 Jan;27(1):51-7.
  2. Saigusa S,Inoue Y,Tanaka T,Toiyama Y,Matsushita K,Kawamura M,Okugawa Y,Hiro J, Uchida K, Mohri Y, Kusunoki M. Impact of solitary single glandular appearance on pathological response and tumor recurrence in patients with rectal cancer after preoperative chemoradiotherapy.Journal of Radiation Oncology.2012；1(4): 363-372.
  3. Inoue Y, Hiro J, Toiyama Y, Tanaka K, Mohri Y, Kusunoki M. Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer. Oncol Lett. 2012 Feb;3(2):363-368.
  4. Toiyama Y, Fujikawa H, Kawamura M, Matsushita K, Saigusa S, Tanaka K, Inoue Y, Uchida K, Mohri Y, Kusunoki M. Evaluation of CXCL10 as a novel serum marker for predicting liver metastasis and prognosis in colorectal cancer. Int J Oncol. 2012 Feb;40(2):560-6.
  5. Saigusa S, Toiyama Y, Tanaka K, Yokoe T, Fujikawa H, Matsushita K, Okugawa Y, Inoue Y, Uchida K, Mohri Y, Kusunoki M. Inhibition of HGF/cMET expression prevents distant recurrence of rectal cancer after preoperative chemoradiotherapy. Int J Oncol. 2012 Feb;40(2):583-91.
  6. Tanaka K, Morimoto Y, Toiyama Y, Okugawa Y, Inoue Y, Uchida K, Kimura K, Mizoguchi A, Kusunoki M. Tanaka K, Morimoto Y, Toiyama Y, Okugawa Y, Inoue Y, Uchida K, Kimura K, Mizoguchi A, Kusunoki M. Microsc Res Tech. 2012 Mar;75(3):307-15.
  7. Kawamoto A, Tanaka K, Saigusa S, Toiyama Y, Morimoto Y, Fujikawa H, Iwata T, Matsushita K, Yokoe T, Yasuda H, Inoue Y, Miki C, Kusunoki M. Clinical significance of radiation-induced CD133 expression in residual rectal cancer cells after chemoradiotherapy. Exp Ther Med. 2012 Mar;3(3):403-409.
  8. Takahashi Y, Mimori K, Yamamoto K, Watanabe M, Tanaka J, Kudo SE, Sugihara K, Hase K, Mochizuki H, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Mori M. Genomic copy number of a carcinogenic single nucleotide polymorphism at 8q24 in non-risk allele colorectal cancer associated with insulin growth factor 2 receptor expression. J Gastroenterol Hepatol. 2012 Apr;27 Suppl 3:95-9.
  9. Inoue M, Uchida K, Otake K, Ishino Y, Koike Y, Kusunoki M. Prognostic significance of glucose transporter-1 (GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy. Surg Today. 2012 May;42(5):460-9.
  10. Kawamura M, Saigusa S, Toiyama Y, Tanaka K, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M. Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy. Anticancer Res. 2012 Apr;32(4):1527-31.
  11. Tanaka K, Morimoto Y, Toiyama Y, Matsushita K, Kawamura M, Koike Y, Okugawa Y, Inoue Y, Uchida K, Araki T, Mizoguchi A, Kusunoki M. In vivo time-course imaging of tumor angiogenesis in colorectal liver metastases in the same living mice using two-photon laser scanning microscopy. J Oncol. 2012;2012:265487.
  12. Tanaka K, Morimoto Y, Toiyama Y, Matsushita K, Kawamura M, Koike Y, Okugawa Y, Inoue Y, Uchida K, Araki T, Mizoguchi A, Kusunoki M. TS and DPD mRNA levels on formalin-fixed paraffin-embedded specimens as predictors for distant recurrence of rectal cancer treated with preoperative chemoradiotherapy. J Surg Oncol. 2012 May;105(6):529-34.
  13. Saigusa S,Inoue Y,Tanaka T,Toiyama Y,Matsushita K,Kawamura M,Okugawa Y,Hiro J, Uchida K, Mohri Y, Kusunoki M. Impact of solitary single glandular appearance on pathological response and tumor recurrence in patients with rectal cancer after preoperative chemoradiotherapy. Journal of Radiation Oncology.2012；1(4): 363-372.
  14. Saigusa S, Toiyama Y, Tanaka K, Okugawa Y, Fujikawa H, Matsushita K, Uchida K, Inoue Y, Kusunoki M. Prognostic significance of glucose transporter-1 (GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy. Surg Today. 2012 May;42(5):460-9.
  15. Toiyama Y, Yasuda H, Saigusa S, Matushita K, Fujikawa H, Tanaka K, Mohri Y, Inoue Y, Goel A, Kusunoki M. Co-expression of hepatocyte growth factor and c-Met predicts peritoneal dissemination established by autocrine hepatocyte growth factor/c-Met signaling in gastric cancer. Int J Cancer. 2012 Jun 15;130(12):2912-21.
  16. Okugawa Y, Toiyama Y, Inoue Y, Iwata T, Fujikawa H, Saigusa S, Konishi N, Tanaka K, Uchida K, Kusunoki M. Clinical significance of serum soluble E-cadherin in colorectal carcinoma. J Surg Res. 2012 Jun 15;175(2):e67-73.
  17. Kashimura N, Kusachi S, Konishi T, Shimizu J, Kusunoki M, Oka M, Wakatsuki T, Sumiyama Y. Impact of surgical site infection after colorectal surgery onhospital stay and medical expenditure in Japan. Surg Today. 2012 Jul;42(7):639-45.
  18. Garcia M, Choi C, Kim HR, Daoud Y, Toiyama Y, Takahashi M, Goel A, Boland CR, Koi M. Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability. Gastroenterology. 2012 Jul;143(1):48-50.
  19. Fujikawa H, Tanaka K, Toiyama Y, Saigusa S, Inoue Y, Uchida K, Kusunoki M. High TrkB expression levels are associated with poor prognosis and EMT induction in colorectal cancer cells. J Gastroenterol. 2012 Jul;47(7):775-84.
  20. Matsushita K, Uchida K, Saigusa S, Ide S, Hashimoto K, Koike Y, Otake K, Inoue M, Tanaka K, Kusunoki M. Glycolysis inhibitors as a potential therapeutic option to treat aggressive neuroblastoma expressing GLUT1. J Pediatr Surg. 2012 Jul;47(7):1323-30.
  21. Matsushita K, Toiyama Y, Tanaka K, Saigusa S, Hiro J, Uchida K, Inoue Y, Kusunoki M. Soluble CXCL16 in Preoperative Serum is a Novel Prognostic Marker and Predicts Recurrence of Liver Metastases in Colorectal Cancer Patients. Ann Surg Oncol. 2012 Jul;19 Suppl 3:518-27.
  22. Ide S, Uchida K, Inoue M, Koike Y, Otake K, Matsushita K, Hashimoto K, Nagano Y, Inoue H, Isaji S, Kusunoki M. Tumor enucleation with preoperative endoscopic transpapillary stenting for pediatric insulinoma. Pediatr Surg Int. 2012 Jul;28(7):707-9.
  23. Kusachi S, Kashimura N, Konishi T, Shimizu J, Kusunoki M, Oka M, Wakatsuki T, Kobayashi J, Sawa Y, Imoto H, Motomura N, Makuuchi H, Tanemoto K, Sumiyama Y. Length of stay and cost for surgical site infection after abdominal and cardiac surgery in Japanese hospitals: multi-center surveillance. Surg Infect (Larchmt). 2012 Aug;13(4):257-65.
  24. Hamada A, Yamakado K, Nakatsuka A, Uraki J, Kashima M, Takaki H, Yamanaka T, Inoue Y, Kusunoki M, Takeda K. Radiofrequency ablation for colorectal liver metastases: prognostic factors in non-surgical candidates. Jpn J Radiol. 2012 Aug;30(7):567-74.
  25. Ishimaru S, Mimori K, Yamamoto K, Inoue H, Imoto S, Kawano S, Yamaguchi R, Sato T, Toh H, Iinuma H, Maeda T, Ishii H, Suzuki S, Tokudome S, Watanabe M, Tanaka J, Kudo SE, Sugihara K, Hase K, Mochizuki H, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Barnard GF, Miyano S, Mori M. Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24.
  26. Okugawa Y, Toiyama Y, Tanaka K, Matsusita K, Fujikawa H, Saigusa S, Ohi M, Inoue Y, Mohri Y, Uchida K, Kusunoki M. Clinical significance of zinc finger E-box binding homeobox 1 (ZEB1) in human gastric cancer. J Surg Oncol. 2012 Sep 1;106(3):280-5.
  27. Saigusa S, Tanaka K, Toiyama Y, Matsushita K, Kawamura M, Okugawa Y, Hiro J, Inoue Y, Uchida K, Mohri Y, Kusunoki M. Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. Oncol Rep. 2012 Sep;28(3):855-61.
  28. Kawamura M, Toiyama Y, Tanaka K, Saigusa S, Okugawa Y, Hiro J, Uchida K, Mohri Y, Inoue Y, Kusunoki M. CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer. Eur J Cancer. 2012 Sep;48(14):2244-51.
  29. Mohri Y, Tanaka K, Ohi M, Toiyama Y, Yasuda H, Inoue Y,Uchida K, Kusunoki M. Inflammation-based Prognostic Score as a Predictor of Postoperative Disease Recurrence in Gastric Cancer. Anticancer Res. 2012 Oct;32(10):4581-4.
  30. Shimwell NJ, Ward DG, Mohri Y, Mohri T, Pallan L, Teng M, Miki YC, Kusunoki M, Tucker O, Wei W, Morse J, Johnson PJ. Macrophage migration inhibitory factor and DJ-1 in gastric cancer: differences between high-incidence and low-incidence areas. Br J Cancer. 2012 Oct 23;107(9):1595-601.
  31. Uchida K, Otake K, Inoue M, Koike Y, Matsushita K, Hashimoto K, Saigusa S, Tanaka K, Inoue Y, Kusunoki M. Unique capsule endoscopic appearance of segmental intestinal dilatation in a child. Pediatr Int. 2012 Oct;54(5):727-9.
  32. Takahashi M, Cuatrecasas M, Balaguer F, Hur K, Toiyama Y, Castells A, Boland CR, Goel A. The Clinical Significance of MiR-148a as a Predictive Biomarker in Patients with Advanced Colorectal Cancer. PLoS One. 2012;7(10):e46684.
  33. Mohri Y, Miki C, Tanaka K, Kawamoto A, Ohi M, Yokoe T, Kusunoki M.Clinical correlations and prognostic relevance of tissue angiogenic factors in patients with gastric cancer. Clin Oncol (R Coll Radiol). 2012 Nov;24(9):610-6.
  34. Inoue Y, Saigusa S, Iwata T, Okugawa Y, Toiyama Y, Tanaka K, Uchida K, Mohri Y, Kusunoki M. The prognostic value of KRAS mutations in patients with colorectal cancer. Oncol Rep. 2012 Nov;28(5):1579-84.
  35. Tanaka K, Okigami M, Toiyama Y, Morimoto Y, Matsushita K, Kawamura M, Hashimoto K, Saigusa S, Okugawa Y, Inoue Y, Uchida K, Araki T, Mohri Y, Mizoguchi A, Kusunoki M. In vivo real-time imaging of chemotherapy response on the liver metastatic tumor microenvironment using multiphoton microscopy. Oncol Rep. 2012 Nov;28(5):1822-30.
  36. Saigusa S, Inoue Y, Tanaka K, Toiyama Y, Matsushita K, Kawamura M, Okugawa Y, Hiro J, Uchida K, Mohri Y, Kusunoki M. Clinical significance of LGR5 and CD44 expression in locally advanced rectal cancer after preoperative chemoradiotherapy. Int J Oncol. 2012 Nov;41(5):1643-52.
  37. Takesue Y, Watanabe A, Hanaki H, Kusachi S, Matsumoto T, Iwamoto A, Totsuka K, Sunakawa K, Yagisawa M, Sato J, Oguri T, Nakanishi K, Sumiyama Y, Kitagawa Y, Wakabayashi G, Koyama I, Yanaga K, Konishi T, Fukushima R, Seki S, Imai S, Shintani T, Tsukada H, Tsukada K, Omura K, Mikamo H, Takeyama H, Kusunoki M, Kubo S, Shimizu J, Hirai T, Ohge H, Kadowaki A, Okamoto K, Yanagihara K. Nationwide surveillance of antimicrobial susceptibility patterns of pathogens isolated from surgical site infections (SSI) in Japan. J Infect Chemother. 2012 Dec;18(6):816-26.
  38. Uchida K, Yoshiyama S, Inoue M, Koike Y, Yasuda H, Fujikawa H, Okita Y, Araki T, Tanaka K, Kusunoki M. Double balloon enteroscopy for pediatric inflammatory bowel disease. Pediatr Int. 2012 Dec;54(6):806-9.

Non-Pub-Med

  1. Inoue Y, Tanaka K, Kusunoki M. Oncology Market Research Indicates Standardization of Colorectal Cancer Chemotherapy. Nova Science Publishers,Inc.33:149-171,2012
  2. Tanaka K, Toiyama Y, Okugawa Y, Hiro J, Kawamoto A, Inoue Y, Uchida K, Araki T, Mohri Y , Kusunoki M. Cytoreductive strategy for multiple intra-abdominal and abdominal wall desmoid tumors in familial adenomatous polyposis: report of three cases. Clinical Journal of Gastroenterology.5:361-366,2012
  3. Toiyama Y, Fujikawa H, Koike Y, Saigusa S, Inoue Y, Tanaka K, Mohri Y, Miki C, Kusunoki M. Evaluation of preoperative C-reactive protein aids in predicting poor survival in patients with curative colorectal cancer with poor lymph node assessment. ONCOLOGY LETTERS.5:1881-1888,2012
  4. Toiyama Y, Ajay G. The Diagnostic, Prognostic, and Predictive Potential of MicroRNA Biomarkers in Colorectal Cancer. Curr Colorectal Cancer Rep. 8:22–31,2012
  5. Otake K, Uchida K, Koike Y, Inoue M, Matsushita K, Hashimoto K, Ide S, Nagano Y, Kusunoki M. Safety and efficacy of Dai-kenchu-to in postoperative infants with gastroschisis. Open J of Pediatrics.2(4):272-277,2012
  6. Koike Y, Uchida K, Kusunoki M. Successful switch-over administration of intravenous-to-oral tacrolimus after isolated living-donor liver transplantation in a child with ultra short gut syndrome. Transpl Int. 25:e29-30, 2012

和文業績

著書

  1. 楠　正人，小林美奈子：第2章　手術部位感染（SSI）B 予防抗菌薬 1.適応,　薬剤選択．日本外科感染症学会（編），周術期感染管理テキスト，診断と治療社，東京，73-77，2012
  2. 毛利靖彦，楠　正人：Ⅱ．消化器疾患の主要症候と鑑別診断.跡見　裕，井廻道夫，北川雄光，下瀬川　徹，田尻久雄，渡辺　守（編），便秘・下痢．生涯教育シリーズ－83　消化器疾患診療のすべて，日本医師会雑誌　第141号　特別号（2），日本医師会，東京，S54-S57，2012
  3. 内田恵一，毛利靖彦，井上幹大，大井正貴，田中光司，楠　正人：Ⅲ各論　１６．腸閉塞　消化器救急疾患―的確に診断するために．杉山正則（監），臨牀消化器内科編集委員会（編），臨牀消化器内科　6月増刊号，文光堂，東京，27(7):188-195，2012
  4. 小林美奈子，楠　正人：第2章　手術部位感染（SSI）C 各種予防策 5.術野消毒と手術時手指衛生．日本外科感染症学会（編），周術期感染管理テキスト，診断と治療社，東京，107-110，2012
  5. 小林美奈子，毛利靖彦，楠　正人：〔テーマ〕入院患者における重症・難治性感染症を診る　コンサルテーション　２．市中で発症した腹膜炎の治療に関するこんな質問．笠原　敬（ゲスト編集），前﨑繁文，大曲貴夫（編集委員），臨床感染症ブックレット　Vol.７，文光堂，東京，148-149，2012

総説

  1. 毛利靖彦，内田恵一，楠　正人：【特集　必読イレウスの診断から治療まで】Ⅰ.機械的イレウス　2. 複雑性または絞扼性イレウスd) 結節形成によるイレウス．外科，74(3)：265-267，2012
  2. 毛利靖彦，楠　正人：感染症．消化器外科学レビュー，229-233，2012
  3. 内田恵一，荒木俊光，井上幹大，小池勇樹，大竹耕平，松下航平，橋本　清，井出正造，長野由佳，楠　正人：5.小児炎症性腸疾患の手術適応．小児科臨床，65(1)：43-49，2012
  4. 内田恵一，荒木俊光，井上幹大，大竹耕平，楠　正人：炎症性腸疾患―病因解明と診断・治療の最新知見―　Ⅷ.　小児における炎症性腸疾患.　「小児炎症性腸疾患に対する外科治療の適応と問題点」，日本臨牀（増刊号），70(1)：500-504，2012
  5. 内田恵一，毛利靖彦，井上幹大，大井正貴，田中光司，楠　正人：【特集 消化器救急疾患－的確に診断するために】Ⅲ　各論16.　腸閉塞．臨牀消化器内科（増刊号），27(7)：926-933，2012
  6. 内田恵一，井上幹大，大竹耕平，小池勇樹，楠　正人：特集　小児炎症性腸疾患の看護　QOLの向上をめざして　知っておきたい知識　「小児炎症性腸疾患の外科治療」．小児看護，35(11)，1448-1454，2012
  7. 井上靖浩，廣　純一郎，田中光司，楠正人：特集：手術助手にはこうしてほしい　Ⅱ.消化管領域　4.結腸右半切除術.外科（別冊），74(1)：41-46，2012
  8. 井上靖浩，田中光司，毛利靖彦，楠　正人：特集　こだわりのデバイス　開腹大腸癌手術におけるこだわりのデバイス：バイポーラシザーズ,粘膜把持鉗子,直腸鉤,ハーモニックスカルペル．手術，66(4)：443-446，2012
  9. 井上靖浩，田中光司，楠　正人：特集　CRT時代の直腸癌手術－最善の戦略は何か[適応，治療法成績]　下部進行直腸癌に対するCRT後の開腹手術．臨床外科，68(3)：265-269，2012
  10. 井上靖浩，田中光司，楠　正人：特集：よくわかるNCD　[NCDへの取り組み]消化器外科②大腸肛門外科．臨床外科，67(6):772-775，2012
  11. 荒木俊光，三木誓雄，楠　正人：特集　大腸疾患をめぐる最近の話題　炎症性腸疾患の治療－最近の進歩－　潰瘍性大腸炎－外科治療－．月刊カレントテラピー，20(7)：13-16，2012
  12. 荒木俊光，井上靖浩，田中光司，内田恵一，楠　正人：炎症性腸疾患―病因解明と診断・治療の最新知見―ⅠⅩ.炎症性腸疾患の癌化　「潰瘍性大腸炎に合併した直腸・肛門管癌の外科治療」，日本臨牀（増刊号），70(1):536-540，2012
  13. 大井正貴，荒木俊光，廣　純一郎，大北喜基，内田恵一，楠　正人：特集　内視鏡手術におけるトラブルシューティング　クローン病に対する腹腔鏡下手術－注意すべきトラブルと対策－．手術，66(8)：1103-1110，2012
  14. 小林美奈子，楠　正人：特集　術前・術後管理必携　Ⅴ.術後合併症とその管理 7.その他　創感染．消化器外科，35(5)：919-921，2012
  15. 大森教成，毛利靖彦，畑田　剛，今井　寛，楠　正人：【消化管救急】疾患別にみたアプローチ　腸閉塞・腸重積．救急医学，36(11)：1532-1535，2012

原著

  1. 毛利靖彦，井上靖浩，楠　正人：特集：手術前に必読　局所解剖　Ⅲ.虫垂・結腸の手術　2.虫垂切除術に必要な局所解剖．外科，74(12)：1307-1310，2012
  2. 毛利靖彦，小林美奈子，楠　正人：【特集周術期合併症発症のリスク評価と適切な対策】　感染症．ICUとCCU，36(7)：501-506，2012
  3. 小林美奈子，毛利靖彦，大北喜基，荒木俊光，井上靖浩，大井正貴，楠　正人：三重大学医学部附属病院における基質拡張型β-ラクタマーゼ(ESBL)産生菌の動向．日本外科感染症学会雑誌，9(1)：9-12，2012
  4. 井上幹大，内田恵一，小池勇樹，大竹耕平，小林美奈子，毛利靖彦，楠　正人：【特集　小児外科と感染症】　小児外科施設における手術部位感染対策．小児外科，44(12)：1128-1132，2012

症例報告

  1. 安田裕美，大井正貴，北嶋貴仁，沖上正人，岩田　崇，井上幹大，毛利靖彦，楠　正人：症例報告　腹腔鏡下脾固定術を施行した遊走脾の１例．日本外科系連会誌．37(6)：1170-1175，2012
  2. 石野義人，問山裕二，井上靖浩，田中光司，毛利靖彦，楠　正人：化学療法が奏功した家族性大腸腺腫症術後腸間膜デスモイドの２例．日本臨床外科学会雑誌，73(1)：160-165，2012
  3. 志村匡信，井上幹大，井出正造，橋本　清，松下航平，小池勇樹，内田恵一，楠　正人：除脈性不整脈により心停止を来たした先天性中枢性肺胞低換気症候群（CCHS）合併　Hirschsprung病（Haddad症候群）の１例．日本小児外科学会雑誌，48(7)，1029-1032，2012

その他

  1. 楠　正人：【外科医が知っておきたい救急処置】　第112回日本外科学会定期学術集会イブニングセミナー　臓器体腔SSIを考える ― 在院日数と医療費に対するSSIの影響．消化器外科，9，S1-S6，2012
  2. 内田恵一，楠　正人：追悼文　　鈴木宏志先生を偲んで．小児外科学会雑誌，48(7):999-1000，2012